Novel pathogenetic mechanisms and therapeutic targets in B cell lymphomas
R. Dalla-Favera
Herbert Irving Comprehensive Cancer Center Columbia University New York, NY, USA
B cell derived Non-Hodgkin Lymphoma (B-NHL), including Burkitt lymphoma (BL and diffuse large B cell lymphoma (DLBCL) developing in children, represent a heterogeneous group of malignancies that arise by malignant transformation of B cells within the germinal center (GC). Within GC, antigen-stimulated B cells undergo rapid proliferation and specific genome remodeling processes such as Immunoglobulin (Ig) somatic hypermutation (SHM), and class switch recombination (CSR).
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