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The prognosis of follicular lymphomas: the F2-project
M. Federico1, M. Bellei1, B. Pro2, A. Lopez-Guillermo3, U. Vitolo4, S. Luminari1
S. Pileri5, P. Solal-Céligny6 on behalf of the IFLPFP
1Univ. Modena e Reggio Emilia, Modena, Italy; 2Univ. Texas, MD Anderson Cancer Center, Houston, USA; 3Hosp.Clin., Barcelona, Spain;4Osp. S.Giovanni B., Torino, Italy 5Univ. Bologna, Bologna, Italy; 6Centre J.Bernard, Le Mans, France
Follicular lymphoma (FL) accounts for 10–15% of non-Hodgkin’s lymphomas in western countries. Although patients with FL experience a relatively indolent course and usually exhibit dramatic responses to initial therapy, they should be considered affected by a fatal malignancy. There is a tendency to relapse over time, the response to salvage treatments is of shorter duration after every relapse, and patients eventually die of disease-related causes. Several treatment approaches are offered to patients with FL; however, criteria to rationalize treatment decisions are still lacking in many instances.
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