Hodgkin’s lymphoma and Grey-zone lymphomas
F. Facchetti, M. Ungari, A. Ubiali
Department of Pathology I University of Brescia, Brescia, Italy
The considerable progress made during the last years in molecular morphology and genotyping of hematopoietic tumors has defined more precise criteria for the diagnosis and classification of Hodgkin (HL) and Non-Hodgkin Lymphomas (NHL). However, a diagnostic grey zone still exists at the interface between HL and NHL, and in some of the cases lack of clear-cut diagnostic criteria represents a problem for both the pathologist and the clinician. These grey-zone lymphomas (GZL) can be defined as distinct lymphomas with marked morphological overlap but no established biological relationship (morphological GZL), or as lymphomas biologically related and with variable, sometimes marked, morphological similarities (biological GZL).