The farnesyl-transferase r115777 and the aminobisphosphonate zoledronic acid synergize on the apoptosis and on the growth inhibition of human cancer cells
Caraglia M,1 Marra M,2 Leonetti C,3 M eo G1, Addeo SR1, Bruzzese F1, Tagliaferri P4, Zupi G3, Abbruzzese A2, Budillon A1
1Experimental Pharmacology, INT Fondaz. Pascale, Naples; 2Dept. Biochemistry and
Biophysics, Second University of Naples; 3IFO- Regina Elena, Roma 4Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro
Pamidronate (PAM) and Zoledronic Acid (ZOL) are aminobisphosphonate (BPs) able to affect the isoprenylation of intracellular small G-proteins. We have investigated the antitumor activity of BPs and R115777 farnesyltransferase inhibitor (FTI) against epidermoid cancer cells. In human epidermoid head and neck KB and lung H1355 cancer cells 48 h exposure to PAM and ZOL induced growth inhibition (IC50 25 µM and 10 µM, respectively) and apoptosis and abolished the proliferative and anti-apoptotic stimuli induced by epidermal growth factor (EGF).
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