Use of cDNA microarrays to estimate gene modulation profiles induced by zoledronic acid treatment in androgen-resistant prostate cancer cell line (PC3)
Santini ,1, Vincenzi B,1 Rosolowski M,2 Altucci L,3 Campioni M,3 Loeffler M2
Baldi A,3 Tonini G1
1Medical Oncology, University Campus Bio-Medico, Rome, Italy; 2Institute for Medical Informatics, University of Leipzig, Germany; 3Section of Pathology, II University, Naples, Italy
The LNCaP and the PC3 cells are widely used as models for prostate cancer. Aminobisphosphonates have clearly demonstrated to inhibit proliferation and induce apoptosis in these cells by interfering with the mevalonate pathway. The types and pattern of downstream genes modulated by zoledronic acid (ZA) treatment are unknown. We used a cDNA microarray platform to analyse the genetic modulation induced by ZA in the PC3 prostate cancer cell line.
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