New insights into the molecular actions of nitrogen-containing bisphosphonates
Rogers MJ
Bone Research Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen,
Scotland, UK
About 10 years ago it was found that mammalian cells could convert some bisphosphonates (BPs) intracellularly into methylene-containing (AppCp-type) analogues of ATP, that accumulate in the cytosol,1,2 reviewed recently.3 Only simple BPs (ie those that most closely resemble PPi, such as clodronate and etidronate, but not alendronate, pamidronate or other N-BPs) appear to be metabolised.2
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