Reciprocal activating interaction between dendritic cells and aminobiphosphonates-stimulated T cells: role of CD86 and inflammatory cytokines
Conti,1 Casetti R,2 Cardone M,1 Varano B,1 Martino A,2 Belardelli F,1 Poccia F2
Gessani S1
1Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy; 2Laboratory of Cellular Immunology, National Institute for Infectious Diseases
"L.Spallanzani", Rome, Italy
Cognate interactions are a common feature of the acquired immune response, where intimate cell contacts govern critical events such as Ag presentation and delivery of T cell help to CTLs and B cells, while the coordinated control of innate immunity is mostly mediated by cytokine loops. However, a number of studies recently highlighted the importance of DC interactions with NK cells, an important effector cell type of innate immunity, in the regulation of DC maturation.1,2,3
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