Alkylamines and bisphosphonates: a common mechanism for activation of
γδ T-cellse
Thompson K, Rogers MJ
*Divisione di Ematologia dell’Università di Torino, Laboratorio di Ematologia Oncologica, Centro di Ricerca in Medicina Sperimentale (CeRMS), Torino; °Divisione di Ematologia dell’Universita’ di Torino, Torino; §Novartis Oncology, Origgio, Varese, Italy
The major subset of gd T-cells in humans (Vg9Vd2+) are activated by three distinct classes of stimulatory molecules: pyrophosphomonoesters, such as isopentenyl diphosphate (IPP) and bromohydrin diphosphate (BrHPP); nitrogen-containing bisphosphonates (N-BPs), such as alendronate (ALN), pamidronate (PAM) and zoledronic acid (ZOL); and alkylamines, such as sec-butylamine (SBA) and iso-butylamine (IBA).
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