Defining The Translocation Mechanism In Therapy-Related Acute Promyelocytic Leukaemia
Anita R. Mistry1, Ashley Mays1, Annabel Mason1, Andreas Reiter2
Joe Wiemels3, Mark Segal3, Ellen Solomon1, Christine Chomienne4 , Pierre Fenaux5
Carolyn Felix6 , David Grimwade1
1Dept. of Medical and Molecular Genetics, King’s College London, UK
2III. Medizinische Universitätsklinik, Mannheim, Germany
3Dept. of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
4Unité de Biologie Cellulaire, Service de Médecine Nucléaire, Hôpital St Louis, Paris, France
5Dept. Of Haematology, Hôpital Avicenne, Bobigny, France
6Dept. of Pediatrics,
University of Pennsylvania School of Medicine,
Philadelphia, Pennsylvania, USA
Acute myeloid leukaemia (AML) occurring in children and younger adults is commonly associated with reciprocal balanced chromosomal translocations, which lead to the formation of chimaeric proteins that play a key role in mediating the leukaemic phenotype (reviewed 1).
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