Therapy-related myeloid leukemia.
A model for leukemogenesis
Michelle M. Le Beau Richard A. Larson
Section of Hematology/Oncology, Department of Medicine and the Cancer Research Center,
University of Chicago, Chicago, IL 60637, USA
Therapy-related acute myeloid leukemia (t-AML) is a distinctive clinical syndrome occurring after exposure to chemotherapy or radiotherapy. t-AML arises in most cases from a multipotential hematopoietic stem cell or, less commonly, in a lineage committed progenitor cell. The prognosis for patients with t-AML is poor, as current forms of therapy are largely ineffective. Molecular analysis and gene expression profiling analysis of t-AML has revealed that there are distinct subtypes of t-AML that have a characteristic gene expression pattern. Establishing the molecular pathways involved in t-AML may facilitate the identification of selectively expressed genes that can be exploited for the development of urgently-needed targeted therapies.
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