Augmenting anti-tumor efficacy of adoptive immunotherapy
with marrow infiltrating lymphocytes
Borrello I
Johns Hopkins University, Baltimore, MD, USA
Despite the ability to generate tumor-specific immunity in both murine and human models, the efficacy of immune-based therapeutic interventions has met with limited success. Effective immunotherapy requires: the precursor frequency of antigen specific T cells be present in sufficient numbers; T cell trafficking to the tumor site; and recognition and killing of their target upon antigen encounter. We have taken a step-wise approach in an effort to address these issues. We utilized a whole tumor cell approach in conjunction with a GM-CSF – producing bystander cell in an effort to prime an immune response towards a broad range of tumor antigens and simplify vaccine production.[>Read full article in PDF]