Pathology of Helicobacter pylori-associated
lymphomas
Axel Greiner Hans K.
Müller-Hermelink
Institute of Pathology, University of Würzburg, Germany
The stomach is the commonest site of MALT-type lymphoma
development, although the gastric mucosa is primarily devoid of
lymphoid tissue. Helicobacter pylori leads to an active chronic
gastritis and to the recruitment to of both B cells and T cells to
mucosa forming mucosa-associated lymphoid tissue (MALT).
In the recent decade evidence accumulated that Helicobacter pylori
infection is linked to the pathogenesis of gastric MALT-type
lymphoma. Antigen- with T-cell stimulation may have important
impact on the initial phase of tumor development, while
Helicobacter pylori eradication can result in tumor regression in
most cases.[>Read full article in PDF]